HPAPI solutions for maximum safety, performance, and longevity

Büchi AG is a leading Swiss manufacturer specializing in HPAPI reactor systems, pilot plants, and high-containment process solutions. With decades expertise, we design and deliver equipment that ensures maximum operator safety, full compliance with cGMP, ATEX, PED, and ASME standards, and optimal process performance across every stage, from R&D and scale-up to full-scale production.

Our HPAPI reactors are fully customized to provide reliable containment for highly potent APIs, meeting the strictest safety and quality requirements while enabling efficient, reproducible, and scalable manufacturing.
When required, our systems can be seamlessly integrated into isolators, ensuring complete high-containment solutions. We work closely with leading isolator manufacturers to deliver customer-oriented, turnkey solutions that combine advanced process technology with the highest level of operator protection.

Key features

• Maximum tightness and easy cleaning through optimized designs
• Seamless integration into containment systems or isolators, developed in collaboration with leading manufacturers
• Wide choice of high-quality materials, including borosilicate glass 3.3, glass-lined steel, fluoropolymers, or Hastelloy®
• Buchiflex® adjustable glass piping system for leak-tight connections and maximum flexibility

 Benefits

• Fully customized to your process and operational requirements
• High cleanability for consistent product purity
• Ensures maximum operator safety with reliable containment for highly potent APIs
• Fully compliant with cGMP, ATEX, PED, and ASME standards
• Delivered with full IQ/OQ documentation and Quality Project Plan (QPP) for smooth validation and regulatory compliance

High containment glass reactors

Our high containment glass reactors from 5 liters to 250 liters are designed for process development, scale up and production of highly potent active pharmaceutical ingredients.

Technical data

• Glass reactor volume 5 to 250 liter
• Pressure range - 1.0 to plus 0.5 bar
• Temperature range - 90 °C to plus 200 °C
• Materials borosilicate glass 3.3, PTFE, PFA, PEEK
• Explosion proof design ATEX with sealed reaction vessel
• CIP capable with optional CIP spray nozzle

Clean room focused design options

• Polished stainless steel components and frames for improved cleanability
• Motors without external ventilation to reduce turbulence in clean room environments
• Polished valves and stainless steel handles
• Buchiflex couplings in polished stainless steel with minimal threaded portion
• Solid cover plate available in Hastelloy® C22 with tri clamp adapter and options for split valve solids dosing

 Handling and integration

• Lifting and lowering device for easy opening, cleaning and stirrer exchange
• Self-draining flexible glass piping and configurable distillation overhead
• Compatibility with temperature control units, nutsche filters, gas scrub